ODCs

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Pyogenic arthritis - pyoderma gangrenosum - acne

1 OMIM reference -
1 associated gene
18 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 6

Familial Mediterranean fever

2 OMIM references -
1 associated gene
39 signs/symptoms

Pyogenic arthritis - pyoderma gangrenosum - acne

Familial Mediterranean fever

PSTPIP1

(UniProt - OMIM)

MEFV

(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	PSTPIP1	(0.65)	MEFV

Citations in the biomedical literature:

Pyogenic arthritis - pyoderma gangrenosum - acne		Familial Mediterranean fever
	Synonym(s): - FRA - Familial recurrent arthritis - PAPA syndrome		Synonym(s): - Benign paroxysmal peritonitis - Benign recurrent polyserositis - FMF - Familial paroxysmal polyserositis - Periodic disease

	Classification (Orphanet): - Rare genetic disease - Rare immune disease - Rare skin disease - Rare systemic or rheumatologic disease		Classification (Orphanet): - Rare genetic disease - Rare immune disease - Rare renal disease - Rare systemic or rheumatologic disease

	Classification (ICD10): (no data available)		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: variable Average age of death: normal Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - No MeSH references		External references: 2 OMIM references - 1 MeSH reference: D010505


COMMON SIGNS	- Arthritis / synovitis / synovial proliferation - Articular / joint pain / arthralgia - Biological inflammatory syndrome / increased erythrocyte sedimentation rate / CRP - Fever / chilling - Lymphadenopathy / polyadenopathies - Proteinuria

Pyogenic arthritis - pyoderma gangrenosum - acne		Familial Mediterranean fever
	Very frequent - Acne / acnea - Asthenia / fatigue / weakness - Autosomal dominant inheritance - Chronic skin infection / ulcerations / ulcers / cancrum - Pustula / pustulosis - Restricted joint mobility / joint stiffness / ankylosis Frequent - Monoclonal immunoglobulins / gammapathy / dysglobulinemia Occasional - Bone marrow failure / pancytopenia - Functional colopathy / irritable bowel syndrome - Furuncle / cutaneous abscess / hidrosadenitis suppurativa - Insulin-dependent / type 1 diabetes - Myositis		Very frequent - Acute abdominal pain / colic - Autosomal recessive inheritance - Constipation - Myalgia / muscular pain - Nausea / vomiting / regurgitation / merycism / hyperemesis Frequent - Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax - Acute diarrhea - Enanthema / aphtosa / aphta / leukoplakia - Erysipela - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Seizures / epilepsy / absences / spasms / status epilepticus - Thoracic / chest pain Occasional - Acute hepatic failure - Acute ischemic syndrome - Angor pectoris / myocardial infarction - Ascitis - Cardiac rhythm disorder / arrhythmia - Cutaneous rash - Edema of the legs / lower limbs - Intestinal obstruction / ileus - Malabsorption / chronic diarrhea / steatorrhea - Meningitis / meningeal syndrome - Mesenteric / intestinal infarction - Motor deficit / trouble - Nephrotic syndrome - Osteoarthritis - Pancreatitis - Pericardium anomalies / pericarditis / absence / cysts / pericardial effusion - Renal disease / nephropathy - Renal / kidney calcifications / nephrocalcinosis - Splenomegaly - Testes inflammation / orchitis - Vascularitis / vasculitides / arteritis